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In the alkaline environment of the small intestine, R-proteins are degraded by pancreatic enzymes, freeing vitamin B 12 to bind to intrinsic factor (IF), a protein secreted by specialized cells in the stomach (parietal cells)
It is a water-soluble vitamin, which means that excess amounts are usually excreted in the urine
The compound showed no hepatotoxicity or nephrotoxicity in healthy participants, but individuals with compromised liver or kidney function metabolise and clear compounds differently
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