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The metabolite 4-OH-E exhibits direct genotoxicity by inducing DNA strand breaks or base oxidation
USA 86 , 70497053 (1989)
For example, reactivating the tumor-suppressive functions of wild-type p53 through small molecules or other approaches may help restore genomic stability and induce apoptosis in cancer cells
1, 2 However, the bodys own GLP-1 has a very short half-life, lasting only one to two minutes in circulation
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