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these cytokines are produced primarily by adipocytes, tissue-resident macrophages, and infiltrating immune cells (e.g., Th17 cells and other T lymphocytes) within the adipose tissue, which can exacerbate keratinocyte activation and immune dysregulation in psoriatic skin (48)

However, such an approach centered on histopathology having some major limitations, more or less explicitly underlined by the WHO Working Group, namely: the diagnostic terminology varies depending on the individual cultural background and on local giudelines (72)

Kokura, S., Wolf, R.E., Yoshikawa, T., Granger, D.N