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Retatrutide has direct human evidence for substantial total and abdominal fat reduction
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A multidisciplinary approach involving gastroenterologists, dietitians, specialist nurses, and potentially endocrinologists offers the best framework for safe, effective weight management in Crohn's disease, ensuring that interventions support rather than compromise overall health
According to prescribing information for GLP-1 receptor agonists, these medications may cause a range of side effects, and individual tolerability varies
Registry and cohort analyses from 2023-2025 suggest that GLP-1 therapies may be used in stable IBD without significantly increasing disease activity, though these studies have important limitations
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