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Obstetrical & Gynecological Survey, 59 (10), 722-746
systemically examined the expression of GPxs in breast cancer cell lines and found that GPx5 and GPx7 were down-regulated in the human breast cancer MCF-7 and MDA-MB-231 cell lines and GPx6 was also down-regulated in MDA-MB-231cells compared with healthy breast MCF-10A cells [19]
In the Walsh framework, toxic overload is one biochemical pattern that may coexist with undermethylation, copper imbalance, pyroluria or other contributors

Overall, these results may be exploited for cancer therapy using inhibitors of enzymes involved in glutamine metabolism or therapeutics that inhibit the transcriptional properties of c-MYC

J.GrossmanC
