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How does Semaglutide help people lose weight

Phase 3 trial data shows that ~28.7% average weight reduction is achieved by 68 weeks, with the largest improvements in metabolic markers fasting glucose, A1c, liver fat, blood pressure typically appearing by month 9

138 short sleep and insomnia as independent predictors of obesity, hypertension, and diabetes

Specifically, liraglutide activates GLP-1 receptors in the brain's appetite centres, promoting feelings of fullness and reducing hunger