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H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults
This route completely bypasses first-pass metabolism in the liver, a major advantage over drugs that are swallowed and processed through the hepatic portal system
The promoter of IGF-1R is CG-rich and lacks TATA and CCAAT elements (LeRoith et al, 1995b), but has elements found in housekeeping genes, containing regulatory elements characteristic for highly regulated genes (Werner et al, 1991)
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