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The first is the nutritional gap argument described above

You should not use semaglutide if you have multiple endocrine neoplasia type 2 (tumors in your glands) or a personal or family history of medullary thyroid cancer

Schedule an appointment if you experience: Sudden or significant decrease in sexual desire that affects your quality of life or relationships New-onset erectile dysfunction or difficulty with arousal Painful intercourse or other physical symptoms during sexual activity Concerning changes in sexual function accompanied by other symptoms such as mood changes, fatigue, or hormonal symptoms New or worsening depression or suicidal thoughts (Zepbound carries a warning for suicidal ideation) Severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis or gallbladder disease requiring urgent evaluation Your physician can conduct a thorough assessment to identify potential underlying causes

The trial involved participants who had previously reached a body weight plateau

2016 Jun 28;9:104-113

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