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Dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes treated with saxagliptin, sitagliptin, or vildagliptin
Mounjaro came in fourth
Standard oral glutathione is therefore not necessarily useless
In contrast, the GLP-1 receptor KO mice had higher AUC glucose than the other groups after 25 and 50 mg, but this was mainly related to the higher fasting glucose, which most likely is a phenomenon explained by exaggerated hepatic glucose production due to absence of GLP-1 action to inhibit liver glucose production, which has been demonstrated in rodents (19) and humans (20, 21) and which may be mediated by insulin and glucagon, but also mediated by GLP-1 receptors located in the portal system (22, 23)
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