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Interestingly, the analogue 23 with six consecutive ureido residues proved to be efficient despite its 7% potency compared to GLP-1-G 2 ( 1 )
However, in scurvy, vitamin C is retained by the brain for neuronal function, and eventual death from the disease is more likely due to lack of vitamin C for collagen synthesis (44)
It is a melanocortin receptor agonist and binds predominantly to the MC 1 receptor
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Our prior work revealed a role for the adipocyte circadian clock in regulating energy balance according to the time when an animal eats through control of creatine-mediated thermogenesis 8
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