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This conversation should cover: The medical necessity of both treatments The expected duration of prednisolone therapy (short-term versus long-term) Individual risk factors, particularly regarding diabetes or prediabetes Realistic expectations about weight loss outcomes whilst on corticosteroids Monitoring requirements for blood glucose and other metabolic parameters The decision to use both medications should be individualised , weighing the clinical benefits of each treatment against potential complications

In fact, according to the lipotoxicity theory, insulin resistance development in peripheral metabolic organs, specifically the liver and skeletal muscle, is caused by cytosolic ectopic accumulation of fatty acid metabolites, such as ceramides and/or diacylglycerols (DAG)