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Notably, a recent review comparing the effects of semaglutide and tirzepatide, derived from STEP 2, SURPASS-1, and SURPASS-2 trials, highlights potential differences in nausea and emesis comparing tirzepatide and semaglutide, suggesting that not only does tirzepatide lead to greater metabolic improvements, but it also appears to be better tolerated by patients in these clinical trials ( 22 )