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The dose is often deliberately high, since most of it passes through and leaves the body

Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

Its a marker, not a mechanism

It is therefore not a competitor of those peptides, but a complementary research angle on the same metabolic field

PLoS Pathog

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