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When comparing ipamorelin vs sermorelin, ipamorelin acts on the ghrelin receptor (GHS-R1a) with high selectivity, producing a GH pulse without affecting cortisol or appetite hormones

2013;30(9):2174-2187.[DOI] 26

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Some individuals naturally have variations in these receptors that may enhance or diminish the medication's effects, though genetic testing for tirzepatide response is not currently part of routine clinical practice