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PD is primarily characterized as a movement disorder, stemming from dopamine depletion in the brain due to the degeneration of dopamine-producing neurons in the substantia nigra (SN), which are crucial for movement coordination

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The formation of AFs-DNA adducts can affect the topology of packaged DNA and DNA conformation (276, 278)

A avaliao individual de cada paciente, considerando seu histrico mdico e suas condies de sade atuais, essencial para tomar decises informadas sobre o uso desse medicamento inovador
