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That said, the compound has not been through full Phase III trials or FDA drug approval
Start your intake What Long-Term GLP-1 Studies Reveal About Safety Clinical trials have evaluated GLP-1 medications over extended periods, with the STEP trials (semaglutide) and SURPASS trials (tirzepatide) tracking outcomes in thousands of patients
Other weight loss approaches Semaglutide is highly effective, but there are other options depending on your needs and preferences
It has the strongest published combination data, but its GLP-1 component is a single agonist, which means it lacks the GIP and glucagon arms that give Retatrutide its higher ceiling and its energy-expenditure edge
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