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Table 1 summarises the baseline characteristics of individuals and baseline demographics of the whole network are summarised in ESM Results
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It is clear, e.g., that mild metabolic acidosis, hypoglycemia, and ketosis are consistent with CVS while severe acidosis or hypoglycemia (in particular non-ketotic hypoglycemia) warrant further evaluation for an inborn error of metabolism, especially in infants and toddlers
Thus, the affinity to IRAP was improved after an enlargement of the P1 as exemplified by 44 (DG026) exhibiting an IC50 of 32 nM while the affinity to ERAP1 dropped 100-fold
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