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Apovian, M.D., DABOM, co-director of the Center for Weight Management and Wellness at Brigham and Womens Hospital and faculty member at Harvard Medical School

A 2016 contemporary meta-analysis of randomized controlled trials of probiotic supplementation found that short-term probiotic consumption decreased intestinal transit time with consistently greater treatment effects in constipated adults, older adults, and with certain probiotic strains.[5] The effect size at the category level is modest, and the heterogeneity across included trials is substantial

It belongs to a class of drugs called thiazolidinediones (TZDs), which work by increasing insulin sensitivity, whereas GLP-1s mimic a natural hormone to regulate appetite and insulin

Seven to nine hours of quality sleep should be considered as important as diet and exercise for weight loss

A 1998 study in Psychoneuroendocrinology (N=24) showed that 8 weeks of sertraline 50 mg blunted peak GH response to the GHRH stimulation test by 28% compared to baseline [7]

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