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That said, the volume of documented results and the specificity of the reported outcomes suggest the platform delivers real value for the right candidate

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Currently, these medications are most appropriately considered for individuals who meet criteria for both binge eating disorder (or recurrent binge eating) and have a body mass index (BMI) within the licensed range for weight management medications

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Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear