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Do not wait for routine labs Severe or persistent abdominal pain, especially with vomiting, needs medical review

The GIP receptor component enhances insulin secretion and may reduce nausea associated with GLP-1 activation

It is also noteworthy that central GLP-1R signaling appears to be impaired in chronic stress conditions or under the influence of a high concentration of glucocorticoids, often observed in patients with depression

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Thus, aversion-related increases in dorsal striatal DA during NPW may be consistent with excitation of dorsolateral SNc DA neurons that project to the dorsal striatum and respond to aversive stimuli [66, 67]