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This results in a pronounced increase in the intratumoral interstitial fluid pressure (IFP), 16 forming an IFP gradient that favors the flow of interstitial fluid from tumors through the surrounding stroma and into areas of lower IFP, thereby enabling tumor cells and tumor-derived compounds to more readily access LNs
Sun et al., in their study, identified the key role of Kla in the immunosuppressive microenvironment and treatment resistance of pancreatic ductal adenocarcinoma (PDAC), where high levels of Kla in PDAC are associated with an immunosuppressive TME, resulting in a reduction in CTLs (96)
Novo Nordisk, the manufacturer behind Wegovy, is currently trialling a once-daily weight loss pill called amycretin
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