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Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders
The R -gene mediated, hypersensitive-type resistance (HR, incompatible interaction) is based on a specific interaction, either directly or indirectly, of a bacterial effector gene product with the R gene of the host plant
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Several factors are recognized to contribute to its development including an overgeneration of reactive oxygen species (ROS)
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