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The four amino acid substitutions in CJC-1295 No DAC (Ala2D-Ala, Asn8Ala, Ala15Ala, Met27Leu) provide resistance to enzymatic degradation while maintaining receptor binding affinity

The exposure achieved with this dose in humans, however, might be too low to reach a sufficiently high GCGR occupancy as observed in this study

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