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A novel approach to treating opioid use disorders: Dual agonists of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors

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While there are notable effects on blood pressure lowering with GLP-1 RAs, limitations of the above trials include only measuring blood pressure variations primarily as secondary endpoints

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This split dosing strategy helps maintain steady plasma concentrations of the active metabolites throughout the 24-hour cycle