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It represents a fundamental shift toward more sophisticated, mechanistically-informed approaches to metabolic disease treatment that address the full complexity of these disorders rather than targeting isolated pathways in isolation

Caulfield VL, Balmer C, Dawson LJ, Smith PM

Within the incretin-based therapy class, early concerns about pancreatitis and pancreatic cancer with GLP-1 receptor agonists have not been substantiated by large-scale studies and meta-analyses

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Thus, a limitation of ethnicity and a potential commercial bias could not be excluded in the study