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Protein-protein interaction (PPI) networking and hub gene analysis of the principal data set from pancreatic islets showed seven out of ten upregulated hub genes were associated with advanced glycation end product (AGE)-receptor of AGE (AGE-RAGE) pathways, while six out of ten downregulated hub genes were related to oxidative phosphorylation (OXPHOS) suggesting that oxidative stress and mitochondrial dysfunction are the key reasons for islet cell failure
Convenient once-weekly dosing improves adherence compared to daily regimens [1]
52:1,711-760 Cantin A et al
Pleiotropic effects of niacin: Current possibilities for its clinical use
On the other hand, VB6 was found not to exhibit an androgenic activity [27]
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