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Individuals with gene mutations such as MTHFR or MTRR have trouble with the process of methylating B12
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National Library of Medicine: Indeed, DNA synthesis is impaired by low vitamin B12, which hampers the activation of folate and, as a result, decreases normal red blood cell production, impairing oxygen delivery [62] WebMD indicates, if you have vitamin B12 deficiency, you could become anemic
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