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The remainder of the iron is in the heme of cytochromes, iron-sulfur center (ISC)-containing proteins, and in non-heme and non-ISC iron-containing proteins

Martin P, de-Witte PAM, Maurice T, Gammaitoni A, Farfel G, Galer B

About 10 percent of people on the highest orforglipron dose stopped the study because of side effects, compared with 2.6 percent of people on the placebo pill

Remember, weight loss is not always linear, and fluctuations are normal

Jos Morales, MD, a vascular neurologist and neurointerventional surgeon at Providence Saint Johns Health Center in Santa Monica, CA, also not involved in this review, told MNT that microglias effect on the neurovascular unit has been associated with dementia. He suggested that: [GLP-1 drugs] could potentially modulate inflammation to reduce the propensity for developing dementias such as Alzheimers disease, particularly in the setting of metabolic syndrome. Morales also explained that in people who have glycemia or type 2 diabetes, the inflammation of the blood-brain barrier can lead to progressive damage to the brain over longer periods. He noted that trials that combine neuroimaging techniques that measure the blood-brain barrier and GLP-1 treatment are needed and could prove that these drugs have neuroprotective benefits.

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