Dilatative Kardiomyopathie (DCM) - Welsh Springer Spaniel globo-product-options Mutation: FNIP2 gene

Mutation: FNIP2 gene

The ATP7A transporter is crucial for copper transport from fibroblasts into the liver and the ATP7B is crucial for copper export from the liver

lack of appetite

swollen lymph nodes

Clinical signs of affected puppies are deafness assessed by abnormal behaviour or by BAER (brainstem auditory evoked response) examinations

Dilatative Kardiomyopathie (DCM) - Welsh Springer Spaniel globo-product-options Mutation: FNIP2 geneDilated Cardiomyopathy (DCM) is a hereditary disease known in animals and humans with many similarities including familial nature, clinical signs and phenotypic features. It is characterised by cardiac enlargement (cardiomegaly) and decreased myocardial function. Due to heart arrhythmias affected individuals suffer from heart failure or collapse. The symptoms in dogs usually occur 20 months postnatal and include ventricular dilation, systolic